3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

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Chemical Name:3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine
CAS No.:181262-42-0
Molecular Formula:C₃₇H₄₅N₅O₅Si
Molecular Weight:667.88
Hs Code.:

Synonyms:3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

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Chemical Property of 3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

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Technology Process of 3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

There total 7 articles about 3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 172842-00-1
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-3-isoadenosine

: 181262-42-0
3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

Guidance literature:: With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1080/07328319608002437

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 181262-42-0
3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / DMAP / pyridine / 0.5 h / 25 °C

2: 81 percent / DMAP, Et₃N / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

With dmap; triethylamine; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319608002437

Reference yield:

: 2273-78-1
3-[beta-D-Ribofuranosyl]-adenine

: 181262-42-0
3-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / pyridine / 6 h / 25 °C

2: 79 percent / tetrahydrofuran / 6 h / 25 °C

3: 76 percent / Bu₄SnCl, AIBN / toluene / 6 h / 75 °C

4: 91 percent / Bu₄NF / tetrahydrofuran / 4 h / 25 °C

5: 45 percent / DMAP / pyridine / 0.5 h / 25 °C

6: 81 percent / DMAP, Et₃N / CH₂Cl₂; dimethylformamide / 12 h / 25 °C

With dmap; 2,2'-azobis(isobutyronitrile); Bu₄SnCl; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1080/07328319608002437