1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

Base Information

Chemical Name:1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester
CAS No.:1383452-44-5
Molecular Formula:C₁₃H₁₁F₃N₂O₂
Molecular Weight:284.238
Hs Code.:

Synonyms:1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

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Chemical Property of 1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

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Technology Process of 1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

There total 2 articles about 1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1383452-43-4
sodium (Z)-3-methoxycarbonyl-3-oxo-1-(4-trifluoromethyl)phenyl-propen-1-olate

: 302-15-8
methylhydrazine sulfuric acid

: 93618-49-6
methyl 1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxylate

: 1383452-44-5
1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

Guidance literature:: sodium (Z)-3-methoxycarbonyl-3-oxo-1-(4-trifluoromethyl)phenyl-propen-1-olate; methylhydrazine sulfuric acid; With acetic acid; at 105 ℃; for 1h; Inert atmosphere;

With sodium hydrogencarbonate; In ethanol;
DOI:10.1016/j.ejmech.2012.03.056

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 93618-49-6
methyl 1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrazole-5-carboxylate

: 1383452-44-5
1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 1 h / 0 - 20 °C

1.2: 24 h / 20 °C

2.1: acetic acid / 1 h / 105 °C / Inert atmosphere

With sodium methylate; acetic acid; In methanol;
DOI:10.1002/jhet.1766