2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

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Chemical Name:2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole
CAS No.:1383452-50-3
Molecular Formula:C₂₁H₁₆F₄N₄O₂S
Molecular Weight:464.443
Hs Code.:

Synonyms:2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

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Chemical Property of 2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

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Technology Process of 2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

There total 3 articles about 2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1383452-46-7
5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazole-3-yl}-1,3,4-oxadiazole-2-thione

: 1383452-50-3
2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1016/j.ejmech.2012.03.056

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1383452-50-3
2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 1 h / 0 - 20 °C

1.2: 24 h / 20 °C

2.1: acetic acid / 1 h / 105 °C / Inert atmosphere

3.1: hydrazine hydrate / methanol / 2 h / 100 °C / Inert atmosphere

4.1: potassium hydroxide / methanol / 65 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With sodium methylate; potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.03.056

Reference yield:

: 1383452-44-5
1-methyl-5-[4-(trifluoromethyl)phenyl]-1Hpyrazole-3-carboxylate acid methyl ester

: 1383452-50-3
2-[2-(2-fluorophenoxy)ethylthio]-5-{5-[4-(trifluoromethyl)phenyl]-1-methyl-1H-pyrazol-3-yl}-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 2 h / 100 °C / Inert atmosphere

2: potassium hydroxide / methanol / 65 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With potassium carbonate; hydrazine hydrate; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.03.056