(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

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Chemical Name:(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt
CAS No.:1437501-99-9
Molecular Formula:C₁₀H₈O₆S₂*C₁₉H₂₆N₄O₂
Molecular Weight:630.743
Hs Code.:

Synonyms:(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

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Chemical Property of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

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Technology Process of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

There total 5 articles about (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437501-98-8
(R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

: 81-04-9
naphthalene-1,5-disulfonate

: 1437501-99-9
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

Guidance literature:: (R)-3-(6-amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester; naphthalene-1,5-disulfonate; In water; acetone; at 10 ℃; Inert atmosphere;

In water; acetone; at 20 - 22 ℃; for 3h;

Reference yield:

: 1254831-47-4
(1-cyclohexyl-1H-imidazol-4-yl)-acetic acid ethyl ester

: 1437501-99-9
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 1 h / 25 - 35 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

2.2: 1 h

3.1: hydrogenchloride / ethanol / 2 h / 25 °C / Reflux

4.1: trifluoroacetic acid / ethanol / Resolution of racemate

5.1: water; acetone / 10 °C / Inert atmosphere

5.2: 3 h / 20 - 22 °C

With hydrogenchloride; sodium ethanolate; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; acetone;

Reference yield:

: 1254831-48-5
3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester

: 1437501-99-9
(R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid ethyl ester naphthalene-1,5-disulfonic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 2 h / 25 °C / Reflux

2.1: trifluoroacetic acid / ethanol / Resolution of racemate

3.1: water; acetone / 10 °C / Inert atmosphere

3.2: 3 h / 20 - 22 °C

With hydrogenchloride; trifluoroacetic acid; In ethanol; water; acetone;