rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

Base Information

Chemical Name:rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester
CAS No.:1198355-08-6
Molecular Formula:C₂₇H₃₂N₂O₇S
Molecular Weight:528.626
Hs Code.:

Synonyms:rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

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Chemical Property of rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

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Technology Process of rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

There total 6 articles about rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1198355-07-5
trans-{4-[(1RS)-1-hydroxy-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]cyclohexyl}carbamic acid benzyl ester

: 124-63-0
methanesulfonyl chloride

: 1198355-08-6
rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;

Reference yield:

: 1198355-04-2
rac-{trans-4-[2-(7-methoxy-2-oxo-2H-quinolin-1-yl)acetyl]cyclohexyl}carbamic acid tert-butyl ester

: 1198355-08-6
rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h

2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

3: sodium hydrogencarbonate / water; acetone / 0 - 20 °C

4: triethylamine / dichloromethane / 0.5 h

With sodium tetrahydroborate; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetone;

Reference yield:

: 1374656-14-0
(4-acetylcyclohexyl)carbamic acid tert-butyl ester

: 1198355-08-6
rac-methanesulfonic acid trans-1-(4-benzyloxycarbonylamino-cyclohexyl)-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloro-trimethyl-silane; lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

1.2: 0.58 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h

4.1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

5.1: sodium hydrogencarbonate / water; acetone / 0 - 20 °C

6.1: triethylamine / dichloromethane / 0.5 h

With sodium tetrahydroborate; chloro-trimethyl-silane; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;