1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

Base Information

Chemical Name:1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea
CAS No.:311819-88-2
Molecular Formula:C₂₁H₂₅N₅O₃
Molecular Weight:395.461
Hs Code.:

1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-<i>tert</i>-butyl-urea

Synonyms:1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

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Chemical Property of 1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

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Technology Process of 1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

There total 4 articles about 1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 293301-09-4
3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine

: 1609-86-5
Tert-butyl isocyanate

: 311819-88-2
1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

: 1-tert-butyl-3-[2-(3-tert-butyl-ureido)-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-7-yl]-urea

Guidance literature:: 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine; With sodium hydride; In N,N-dimethyl-formamide;

Tert-butyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/jm000161d

Reference yield:

: 311820-00-5
3-(3,5-dimethoxyphenyl)-N⁷-trityl-1,6-naphthyridine-2,7-diamine

: 311819-88-2
1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.03 h / 20 °C

1.2: dimethylformamide / 2 h / 20 °C

2.1: silica gel / CH₂Cl₂ / 48 h / 20 °C

3.1: NaH / dimethylformamide

3.2: 93 percent / dimethylformamide / 24 h / 20 °C

With silica gel; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000161d

Reference yield:

: 311819-99-5
3-(3,5-dimethoxyphenyl)-7-(tritylamino)-1,6-naphthyridin-2-ylformamide

: 311819-88-2
1-[7-amino-3-(3,5-dimethoxy-phenyl)-[1,6]naphthyridin-2-yl]-3-tert-butyl-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 79 percent / aq. NaOH / methanol; CH₂Cl₂ / 2.5 h / 40 °C

2.1: NaH / dimethylformamide / 0.03 h / 20 °C

2.2: dimethylformamide / 2 h / 20 °C

3.1: silica gel / CH₂Cl₂ / 48 h / 20 °C

4.1: NaH / dimethylformamide

4.2: 93 percent / dimethylformamide / 24 h / 20 °C

With sodium hydroxide; silica gel; sodium hydride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000161d