(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

Base Information

Chemical Name:(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate
CAS No.:1361050-77-2
Molecular Formula:C₂₀H₂₁F₆N₅O₃
Molecular Weight:493.409
Hs Code.:

Synonyms:(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

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Chemical Property of (R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

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Technology Process of (R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

There total 3 articles about (R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1361050-76-1
(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

: 486460-21-3
3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

: 1361050-77-2
(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

Guidance literature:: (R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; In tetrahydrofuran; for 12h; Reflux;

With sodium hydroxide; In water;

Reference yield:

: 1361050-65-8
(E)-1-benzyl-4-methyl-2-(2,4,5-trifluorobenzylidene)succinate

: 1361050-77-2
(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2250.23 Torr

2.1: (+)-cinchonine / acetone / Resolution of racemate; Reflux

3.1: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

4.1: sodium hydroxide; water / methanol / 4 h / 20 °C

4.2: 20 °C / pH 2

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 °C / Inert atmosphere

5.2: 12 h / Reflux

With (+)-cinchonine; diphenyl phosphoryl azide; water; hydrogen; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetone; 3.1: Curtius Rearrangement;

Reference yield:

: 1361050-70-5
(R)-4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

: 1361050-77-2
(R)-isopropyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: 20 °C / pH 2

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 12 h / Reflux

With diphenyl phosphoryl azide; water; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; 1.1: Curtius Rearrangement;