1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Base Information

Chemical Name:1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine
CAS No.:124424-36-8
Molecular Formula:C₂₉H₂₆FN₃O₄
Molecular Weight:499.542
Hs Code.:

Synonyms:1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Suppliers and Price of 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

There total 8 articles about 1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69123-98-4
fialuridine

: 124424-36-8
1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Guidance literature:: Multi-step reaction with 7 steps

1: 90.3 percent / H₂, Et₃N / 10percent Pd/C / methanol; H₂O / 18 h / 2068.6 Torr

2: 89.3 percent / pyridine / 18 h / Ambient temperature

3: 100 percent / pyridine / 16 h / 0 °C

4: 83.5 percent / 1 N aq. NaOH / ethanol / 4 h / Heating

5: 95.2 percent / t-BuOK / dimethylsulfoxide / 1 h / Ambient temperature

6: p-chlorophenyl phosphodichloridate, pyridine / 72 h / Ambient temperature

7: conc. aq. NH₃ / dioxane / 5 h / Ambient temperature

With pyridine; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; hydrogen; triethylamine; 4-chlorophenylphosphorodichloridate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00170a017

Reference yield:

: 1-{(2R,5S)-3-Fluoro-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,5-dihydro-furan-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

: 124424-36-8
1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; for 5h; Yield given; Ambient temperature;
DOI:10.1021/jm00170a017

Reference yield:

: 124424-27-7
1-<5-O-(momomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>uracil

: 124424-36-8
1-<5-O-(monomethoxytrityl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl>cytosine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridine / 16 h / 0 °C

2: 83.5 percent / 1 N aq. NaOH / ethanol / 4 h / Heating

3: 95.2 percent / t-BuOK / dimethylsulfoxide / 1 h / Ambient temperature

4: p-chlorophenyl phosphodichloridate, pyridine / 72 h / Ambient temperature

5: conc. aq. NH₃ / dioxane / 5 h / Ambient temperature

With pyridine; ammonium hydroxide; sodium hydroxide; potassium tert-butylate; 4-chlorophenylphosphorodichloridate; In 1,4-dioxane; ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00170a017