(1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide

Base Information

• Chemical Name: (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide
• CAS No.: 1273232-35-1
• Molecular Formula: C₁₆H₂₆INO₅*HI
• Molecular Weight: 567.203
• Mol file: 1273232-35-1.mol

Synonyms:(1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide

Chemical Property of (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide

There total 2 articles about (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethanol (64-17-5) + tert-butyl (2R,2'S,3'S,4'R,αR,Z)-2-hydroxy-2-[N(1')-α-methyl-p-methoxybenzyl-3',4'-O-isopropylidene-1',2',3',4',7',8'-hexahydroazocin-2'-yl]ethanoate → (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide (1273232-35-1) + α-methyl-p-methoxybenzyl ethyl ether (67233-95-8)

Guidance literature:

With iodine; sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/ol103090z

Reference yield:

tert-butyl (2R,3S,4S,5R,αR)-2-hydroxy-3-[N-but-3'-enyl-N-(α-methyl-p-methoxybenzyl)amino]-4,5-O-isopropylidenehept-6-enoate (1273232-31-7) → (1R,2S,3S,7S,7aS,1'R)-1,2-O-isopropylidene-3-(1'-hydroxy-2'-tert-butoxy-2'-oxoethyl)-7-iodooctahydropyrolizinium iodide (1273232-35-1) + α-methyl-p-methoxybenzyl ethyl ether (67233-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Grubbs catalyst first generation / dichloromethane / 12 h / 20 °C

2: iodine; sodium hydrogencarbonate / dichloromethane / 12 h / 20 °C

With Grubbs catalyst first generation; iodine; sodium hydrogencarbonate; In dichloromethane;

DOI:10.1021/ol103090z

upstream raw materials:

tert-butyl (2R,3S,4S,5R,αR)-2-hydroxy-3-[N-but-3'-enyl-N-(α-methyl-p-methoxybenzyl)amino]-4,5-O-isopropylidenehept-6-enoate

ethanol

Refernces