4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

Base Information

Chemical Name:4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate
CAS No.:1421369-93-8
Molecular Formula:C₂₄H₂₂ClF₃O₃
Molecular Weight:450.885
Hs Code.:

Synonyms:4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

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Chemical Property of 4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

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Technology Process of 4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

There total 10 articles about 4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1409956-58-6
2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen-1(2H)-one

: 407-25-0
trifluoroacetic anhydride

: 1421369-93-8
4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 3.5h;

Reference yield: 96.0%

: trans-2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen-1(2H)-one

: 407-25-0
trifluoroacetic anhydride

: 1421369-93-8
4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1421369-93-8
4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium; iodine / tetrahydrofuran / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 6 h / 110 °C / Dean-Stark

3.1: 3 % platinum on carbon; hydrogen / ethyl acetate / 7 h / 20 °C / 3750.38 - 5250.53 Torr / Autoclave

4.1: toluene-4-sulfonic acid / acetone; water / 3 h / 70 °C

5.1: titanium tetrachloride / dichloromethane / -35 - 0 °C / Inert atmosphere

5.2: 1 h / -55 °C / Inert atmosphere

6.1: dmap; pyridine / dichloromethane / 0 - 20 °C

With pyridine; dmap; 3 % platinum on carbon; hydrogen; iodine; titanium tetrachloride; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; dichloromethane; water; ethyl acetate; acetone; toluene; 5.1: |Mukaiyama Aldol Addition / 5.2: |Mukaiyama Aldol Addition;