(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

Base Information

Chemical Name:(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate
CAS No.:1383707-43-4
Molecular Formula:C₁₉H₁₈O₅
Molecular Weight:326.349
Hs Code.:

Synonyms:(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

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Chemical Property of (E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

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Technology Process of (E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

There total 3 articles about (E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 922-67-8
propynoic acid methyl ester

: 169137-67-1
(4-benzyloxy-2-iodo-5-methoxyphenyl)methanol

: 1383707-43-4
(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

: 1383707-42-3
(Z)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

Guidance literature:: propynoic acid methyl ester; (4-benzyloxy-2-iodo-5-methoxyphenyl)methanol; With triphenylphosphine; In acetonitrile; for 1h; Inert atmosphere; Reflux;

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 9h; optical yield given as %de; stereoselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/ol301154f

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1383707-43-4
(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

: 1383707-42-3
(Z)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / methanol / 0 °C / Inert atmosphere

2.1: iodine; silver trifluoroacetate / chloroform / 2.17 h / 22 °C / Inert atmosphere

3.1: triphenylphosphine / acetonitrile / 1 h / Inert atmosphere; Reflux

3.2: 9 h / 20 °C / Inert atmosphere; Reflux

With sodium tetrahydroborate; iodine; silver trifluoroacetate; triphenylphosphine; In methanol; chloroform; acetonitrile; 3.1: Michael condensation / 3.2: Heck reaction;
DOI:10.1021/ol301154f

Reference yield:

: 33693-48-0
4-benzyloxy-3-methoxybenzyl alcohol

: 1383707-43-4
(E)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

: 1383707-42-3
(Z)-methyl 2-[6-(benzyloxy)-5-methoxyisobenzofuran-1(3H)-ylidene]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; silver trifluoroacetate / chloroform / 2.17 h / 22 °C / Inert atmosphere

2.1: triphenylphosphine / acetonitrile / 1 h / Inert atmosphere; Reflux

2.2: 9 h / 20 °C / Inert atmosphere; Reflux

With iodine; silver trifluoroacetate; triphenylphosphine; In chloroform; acetonitrile; 2.1: Michael condensation / 2.2: Heck reaction;
DOI:10.1021/ol301154f