1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL

Base Information

• Chemical Name: 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL
• CAS No.: 118724-05-3
• Molecular Formula: C3H6 N4
• Molecular Weight: 98.1074
• Hs Code.: 2933990090
• Mol file: 118724-05-3.mol

Synonyms:1H-1,2,3-Triazole-4-methanamine(9CI)

Chemical Property of 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL

Chemical Property:

• Vapor Pressure: 0.0013mmHg at 25°C
• Melting Point: 140 °C (sublm)(Press: 0.01 Torr)
• Refractive Index: 1.598
• Boiling Point: 298°C at 760 mmHg
• PKA: 7.14±0.70(Predicted)
• Flash Point: 159.2°C
• PSA: 67.59000
• Density: 1.322g/cm³
• LogP: -0.03630

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1H-1,2,3-Triazol-4-yl)methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-[1,2,3]Triazol-4-ylmethylamine HCl is used in the preparation of optimized 5-membered heterocycle-linked pterins for inhibition of ricin toxin A. Also used in the synthesis of orally bioavailiable human neurokinin-1 (hNK1) antagonists.

Technology Process of 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL

There total 3 articles about 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-azidomethyl-1,2,3-triazole → (1H-[1,2,3]triazol-4-yl)methanamine (118724-05-3)

Guidance literature:

4-azidomethyl-1,2,3-triazole; With triphenylphosphine; In diethyl ether; at 20 ℃; for 24h;

In tetrahydrofuran; water; for 1.5h; Reflux;

DOI:10.3998/ark.5550190.p009.846

Reference yield: 39.0%

Propargylamine (2450-71-7) → (triazole-5-yl)methanamine + (1H-[1,2,3]triazol-4-yl)methanamine (118724-05-3)

Guidance literature:

Propargylamine; With azidopolyethyleneglycol monomethyl ether; In toluene; at 70 ℃; for 48h;

With formic acid; In chloroform; for 7h; Heating;

DOI:10.1016/j.tet.2005.03.049

Reference yield:

propargyl p-toluenesulfonate (6165-76-0) → (1H-[1,2,3]triazol-4-yl)methanamine (118724-05-3)

Guidance literature:

With ammonium hydroxide; sodium azide; Yield given. Multistep reaction; 1.) H₂O, dioxane, RT, 36 h; 2.) 50-60 deg C, 3 d;

upstream raw materials:

propargyl p-toluenesulfonate

Propargylamine

Downstream raw materials:

(1H-1,2,3-triazol-4-yl)methanol

Refernces

• 1、 Banert, Klaus,Hagedorn, Manfred,Hemeltjen, Claudia,Ihle, Andreas,Weigand, Kevin,Priebe, Hanno. "Synthesis of N-unsubstituted 1,2,3-triazoles via a cascade including propargyl azides, allenyl azides, and triazafulvenes". . p. 338 - 361. Retrieved 2016/11/21.