Technology Process of 3-oxo-1-cyclohexen-1-yl 1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylate
There total 5 articles about 3-oxo-1-cyclohexen-1-yl 1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1,6-dihydro-6-oxo-1,2-diphenyl-5-pyrimidinecarboxylic acid;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
1,3-cylohexanedione;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C
1.2: 1 h / 20 °C
2.1: ammonium chloride / acetonitrile / 2 h / Reflux
3.1: pyridine; lithium iodide / 24 h / Reflux
3.2: pH 7
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
4.2: 0.5 h / 20 °C
With
pyridine; oxalyl dichloride; sodium hexamethyldisilazane; ammonium chloride; lithium iodide;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonium chloride / acetonitrile / 2 h / Reflux
2.1: pyridine; lithium iodide / 24 h / Reflux
2.2: pH 7
3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
3.2: 0.5 h / 20 °C
With
pyridine; oxalyl dichloride; ammonium chloride; lithium iodide;
N,N-dimethyl-formamide;
In
dichloromethane; acetonitrile;
