2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

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Chemical Name:2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol
CAS No.:1270029-76-9
Molecular Formula:C₁₈H₂₂F₂N₄O₂
Molecular Weight:364.395
Hs Code.:

Synonyms:2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

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Chemical Property of 2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

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Technology Process of 2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

There total 10 articles about 2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270029-75-8
{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}acetic acid hydrochloride

: 1270029-76-9
2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

Guidance literature:: {5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}acetic acid hydrochloride; With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

With ammonium hydroxide; In methanol; dichloromethane;

Reference yield:

: 951127-25-6
N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester

: 1270029-76-9
2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 1 h / 20 °C

1.2: 18 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: hydrogenchloride / water / 0.08 h

4.1: hydrogenchloride; water / 1 h / 20 - 100 °C / Microwave irradiation

5.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; trifluoroacetic acid; In methanol; dichloromethane; water;

Reference yield:

: 6573-19-9,769895-06-9
1,4,5,6-tetrahydropyrrolo[3, 4-c]pyrazole

: 1270029-76-9
2-{5-[(3R,5S,6R)-5-amino-6-(2,5-difluorophenyl)tetrahydro-2H-pyran-3-yl]-5,6-dihydropyrrolo[3,4-c]pyrazol-2(4H)-yl}ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: sodium hydride / acetonitrile; mineral oil / 2 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

4.1: methanol / 1 h / 20 °C

4.2: 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: hydrogenchloride / water / 0.08 h

7.1: hydrogenchloride; water / 1 h / 20 - 100 °C / Microwave irradiation

8.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; acetonitrile; mineral oil;