N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

Base Information

Chemical Name:N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide
CAS No.:882175-62-4
Molecular Formula:C₃₂H₅₁NO₆Si
Molecular Weight:573.846
Hs Code.:

<i>N</i>-{2-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-<i>N</i>-(4-methoxy-benzyloxy)-3-oxo-propionamide

Synonyms:N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

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Chemical Property of N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

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Technology Process of N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

There total 12 articles about N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 882175-60-2
(S)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-(4-methoxy-benzyloxyamino)-propan-1-ol

: 13898-94-7
3-cyclohexyl-3-oxopropanoic acid

: 882175-62-4
N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate;
DOI:10.3987/com-05-s(t)70

Reference yield:

: 3413-44-3
(R)-2-cyclohexen-1-ol

: 882175-62-4
N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 84 percent / imidazole / CH₂Cl₂

2.1: m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 0 °C

3.1: [C(CH₃)2(CH₂)3C(CH₃)2]NLi / hexane; benzene / 0 - 20 °C

4.1: 87 percent / tri-n-butylphosphine / CH₂Cl₂ / 0.08 h / 22 °C

5.1: 86 percent / DIBAL / toluene

6.1: 97 percent / imidazole / CH₂Cl₂

7.1: toluene / 180 °C

8.1: PPTs; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

8.2: NaCNBH₃ / acetic acid / 10 °C

9.1: 95 percent / benzotriazol-1-yloxytris(Me₂N)phosphonium hexaFphosphate

With 1H-imidazole; tributylphosphine; 4 A molecular sieve; 2,2,6,6-tetramethylpiperidinyl-lithium; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane; toluene; benzene;
DOI:10.3987/com-05-s(t)70

Reference yield:

: 882175-52-2
tert-butyl-(cyclohex-2-enyloxy)-dimethyl-silane

: 882175-62-4
N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: m-chloroperbenzoic acid; NaHCO₃ / CH₂Cl₂ / 0 °C

2.1: [C(CH₃)2(CH₂)3C(CH₃)2]NLi / hexane; benzene / 0 - 20 °C

3.1: 87 percent / tri-n-butylphosphine / CH₂Cl₂ / 0.08 h / 22 °C

4.1: 86 percent / DIBAL / toluene

5.1: 97 percent / imidazole / CH₂Cl₂

6.1: toluene / 180 °C

7.1: PPTs; 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

7.2: NaCNBH₃ / acetic acid / 10 °C

8.1: 95 percent / benzotriazol-1-yloxytris(Me₂N)phosphonium hexaFphosphate

With 1H-imidazole; tributylphosphine; 4 A molecular sieve; 2,2,6,6-tetramethylpiperidinyl-lithium; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 3-chloro-benzenecarboperoxoic acid; In hexane; dichloromethane; toluene; benzene;
DOI:10.3987/com-05-s(t)70