882175-52-2

Upstream product

• 61426-49-1 (1R)-2-bromocyclohex-2-en-1-ol 
• 50870-61-6 2-bromocyclohex-2-en-1-one 
• 3413-44-3 (R)-2-cyclohexen-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 882175-69-1 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1-(4-methoxy-benzyloxy)-1H-pyridin-2-one 
• 882175-66-8 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1-(4-methoxy-benzyloxy)-5,6-dihydro-1H-pyridin-2-one 
• 882175-63-5 N-{(S)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)-N-(4-methoxy-benzyloxy)-3-oxo-propionamide 
• 882175-65-7 5-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-cyclohexanecarbonyl-4-hydroxy-1-(4-methoxy-benzyloxy)-5,6-dihydro-1H-pyridin-2-one 
• 882175-62-4 N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-3-cyclohexyl-N-(4-methoxy-benzyloxy)-3-oxo-propionamide 
• 882175-70-4 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-((1S,2S,4aR,6S,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-4-hydroxy-1H-pyridin-2-one 
• 930093-57-5 5-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-cyclohexanecarbonyl-1-(4-methoxy-benzyloxy)-1H-pyridin-2-one 
• 882175-64-6 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-4-hydroxy-1-(4-methoxy-benzyloxy)-2-oxo-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester 
• 882175-61-3 N-{2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-hydroxy-propyl}-N-(4-methoxy-benzyloxy)-malonamic acid ethyl ester 
• 930093-51-9 5-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-1-(4-methoxy-benzyloxy)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 882175-60-2 (S)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-(4-methoxy-benzyloxyamino)-propan-1-ol 
• 882175-57-7 (3R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-((E)-3-triethylsilanyloxy-propenyloxy)-cyclohexene 
• 882175-58-8 (R)-2-[(1R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyl]-3-triethylsilanyloxy-propionaldehyde 
• 882175-71-5 (E)-3-[(1R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-cyclohex-2-enyloxy]-acrylic acid methyl ester 

Relevant academic research and scientific papers

An enantiocontrolled approach for the synthesis of chiral 3,5-disubstituted 2(1H)-pyridinones

An enantioselective route for the convergent synthesis of chiral, nonracemic 5-substituted 3-acyl-2(1H)-pyridinones is reported. Claisen rearrangement provides direct access to the α-branched 2-[4-(tert-butyldimethylsilanoxy)cyclohex-2-enyl]-3-hydroxypropionaldehyde as a key intermediate. The application of mild oxidation conditions facilitates the preparation of a series of 3,5-disubstituted 2(1H)-pyridinones.