2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol

Base Information

• Chemical Name: 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol
• CAS No.: 760980-11-8
• Molecular Formula: C₂₂H₃₁BrO₃Si
• Molecular Weight: 451.476

Synonyms:2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol

Chemical Property of 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol

Chemical Property:

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Technology Process of 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol

There total 2 articles about 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-bromo-6-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-1-phenyl-ethyl]-phenol (760980-10-7) + methyl iodide (74-88-4) → 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol (760980-11-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1021/ja040091q

Reference yield:

7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-3H-benzofuran-2-one (321527-38-2) → 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol (760980-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / LiBH₄ / tetrahydrofuran / 8 h / 25 °C

2: 94 percent / K₂CO₃ / dimethylformamide / 2 h / 25 °C

With lithium borohydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja040091q

Reference yield: 87.0%

2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol (760980-11-8) → 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propionaldehyde (760979-79-1)

Guidance literature:

With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja040091q

upstream raw materials:

2-bromo-6-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-1-phenyl-ethyl]-phenol

methyl iodide

7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-3H-benzofuran-2-one

Downstream raw materials:

2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propionaldehyde

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