(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

Base Information

Chemical Name:(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine
CAS No.:1400996-43-1
Molecular Formula:C₁₇H₁₉ClN₄O
Molecular Weight:330.817
Hs Code.:

Synonyms:(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

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Chemical Property of (RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

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Technology Process of (RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

There total 8 articles about (RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1400997-63-8
tert-butyl (RS)-2-(3-chloro-4-(5-cyclopropylpyrimidin-2-ylamino)phenyl)morpholine-4-carboxylate

: 1400996-43-1
(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

Guidance literature:: tert-butyl (RS)-2-(3-chloro-4-(5-cyclopropylpyrimidin-2-ylamino)phenyl)morpholine-4-carboxylate; With water; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 3h;

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; acetonitrile; at 20 ℃;

Reference yield:

: 1400997-61-6
tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

: 1400996-43-1
(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 17 h / 20 - 60 °C

2.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere

3.1: trifluoroacetic acid; water / acetonitrile / 3 h / 80 °C

3.2: 20 °C

With hydroxylamine hydrochloride; water; sodium acetate; caesium carbonate; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; acetonitrile; 2.1: Buchwald-Hartwig Reaction;

Reference yield:

: 1400997-62-7
tert-butyl (RS)-2-(4-amino-3-chlorophenyl)morpholine-4-carboxylate

: 1400996-43-1
(RS)-N-(2-chloro-4-(morpholin-2-yl)phenyl)-5-cyclopropylpyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere

2.1: trifluoroacetic acid; water / acetonitrile / 3 h / 80 °C

2.2: 20 °C

With water; caesium carbonate; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; acetonitrile; 1.1: Buchwald-Hartwig Reaction;