tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

Base Information

Chemical Name:tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate
CAS No.:1400997-61-6
Molecular Formula:C₂₈H₂₉ClN₂O₃
Molecular Weight:477.003
Hs Code.:

Synonyms:tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

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Chemical Property of tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

Chemical Property:

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Technology Process of tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

There total 6 articles about tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1013-88-3
Benzophenone imine

: 1400997-60-5
tert-butyl (RS)-2-(4-bromo-3-chlorophenyl)morpholine-4-carboxylate

: 1400997-61-6
tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In toluene; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 21900-32-3
4-bromo-3-chlorobenzoyl chloride

: 1400997-61-6
tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethyl ether; acetonitrile; tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: tetrahydrofuran / 7 h / 20 °C

3.1: dichloromethane / 0 - 20 °C

4.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 0.5 h / 0 - 20 °C

5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 16 h / 90 °C / Inert atmosphere

With methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; acetonitrile; 5.1: Buchwald-Hartwig Reaction;

Reference yield:

: 1400997-57-0
(RS)-2-(4-bromo-3-chloro-phenyl)-oxirane

: 1400997-61-6
tert-butyl (RS)-2-(3-chloro-4-(diphenylmethyleneamino)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 7 h / 20 °C

2.1: dichloromethane / 0 - 20 °C

3.1: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 0.5 h / 0 - 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / toluene / 16 h / 90 °C / Inert atmosphere

With methanesulfonyl chloride; triethylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane; toluene; 4.1: Buchwald-Hartwig Reaction;