2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Base Information

Chemical Name:2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
CAS No.:1239963-50-8
Molecular Formula:C₃₄H₄₀ClF₃N₂O₃SSi
Molecular Weight:677.303
Hs Code.:

Synonyms:2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Chemical Property of 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Technology Process of 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

There total 14 articles about 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1239964-35-2
(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorophenyl)methanol

: 1239963-85-9
5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol

: 1239963-50-8
2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 24h;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239963-50-8
2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 9 steps

1: sulfuric acid / 20 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

3: tetrahydrofuran / 2 h / -78 - 20 °C

4: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

7: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8: acetic acid / 4 h / Reflux

9: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h

With hydrogenchloride; dmap; sodium azide; tetra-n-butylammonium tribromide; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1239963-50-8
2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / -78 - 20 °C

2: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: acetic acid / 4 h / Reflux

7: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h

With hydrogenchloride; sodium azide; tetra-n-butylammonium tribromide; di-isopropyl azodicarboxylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;