2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Base Information

Chemical Name:2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
CAS No.:1239963-58-6
Molecular Formula:C₂₈H₂₅ClF₃N₅O₂S
Molecular Weight:588.053
Hs Code.:

Synonyms:2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Chemical Property of 2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

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Technology Process of 2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

There total 14 articles about 2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1239963-57-5
2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenoxy)ethyl methanesulfonate

: 1239963-58-6
2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 1239963-80-4
3-(4-chloro-3-methoxyphenyl)-3-methyl-2-methylbutan-2-one

: 1239963-58-6
2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 8 steps

1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 3 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

3: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

4: acetic acid / 4 h / Reflux

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

6: hydrogen fluoride / acetonitrile / 1 h

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

8: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

With hydrogenchloride; sodium azide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; tetra-N-butylammonium tribromide; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1239963-81-5
1-bromo-3-(4-chloro-3-methoxyphenyl)-3-methyl-2-methylbutan-2-one

: 1239963-58-6
2-(4-(2-azidoethoxy)-2,6-difluorobenzylthio)-5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

2: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol; water / 5 h / 2068.65 - 3361.55 Torr

3: acetic acid / 4 h / Reflux

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24 h

5: hydrogen fluoride / acetonitrile / 1 h

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 - 20 °C

7: sodium azide / N,N-dimethyl-formamide / 1 h / 0 °C

With hydrogenchloride; sodium azide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;