N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

Base Information

Chemical Name:N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide
CAS No.:245365-02-0
Molecular Formula:C₂₂H₂₀ClFN₂O₄S
Molecular Weight:462.929
Hs Code.:

<i>N</i>-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

Synonyms:N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

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Chemical Property of N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

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Technology Process of N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

There total 4 articles about N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 245365-02-0
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

3: TFA / CH₂Cl₂

4: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 213015-69-1
tert-butyl 2-{[(4-fluorophenyl)sulfonyl]amino}acetate

: 245365-02-0
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

2: TFA / CH₂Cl₂

3: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

: 245364-73-2
[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

: 245365-02-0
N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: CBr₄, NEt₃, polymer-supported triphenylphosphine / CH₂Cl₂

With PS-triphenylphosphine; carbon tetrabromide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(99)00311-X