((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Base Information

Chemical Name:((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate
CAS No.:1450904-92-3
Molecular Formula:C₂₀H₂₁FO₅S
Molecular Weight:392.448
Hs Code.:

Synonyms:((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Suppliers and Price of ((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 13 raw suppliers

Chemical Property of ((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Chemical Property:

Purity/Quality:: 98% ,99% , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

There total 6 articles about ((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4124-41-8
p-toluenesulfonylanhydride

: 1369768-29-5
[(1R,2S)-2-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropyl]-methyl acetate

: 1450904-92-3
((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Guidance literature:: With pyridine; In 2-methyltetrahydrofuran; at 10 - 15 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1450905-00-6
(1S,2R)-1-(3-fluorophenyl)-2-(hydroxymethyl)cyclopropane-1-carboxylic acid

: 1450904-92-3
((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol; water / 2 h / 60 °C

2: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

3: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

4: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium borohydride; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;

Reference yield:

: 501-00-8
3-fluorophenylacetonitrile

: 1450904-92-3
((1R,2S)-2-(3-fluorophenyl)-2-((p-tosyloxy)methyl)cyclopropyl)methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 29 h / -3 - 7 °C

2: potassium hydroxide; water / ethanol / 5 h / 80 °C

3: hydrogenchloride / ethanol; water / 2 h / 60 °C

4: lithium borohydride / tetrahydrofuran; 2-methyltetrahydrofuran / -10 - 25 °C / Inert atmosphere

5: Candida Antarctica Lipase B / 2-methyltetrahydrofuran / 20 - 25 °C / Inert atmosphere; Enzymatic reaction

6: pyridine / 2-methyltetrahydrofuran / 1 h / 10 - 15 °C / Inert atmosphere

With pyridine; hydrogenchloride; lithium borohydride; water; sodium hexamethyldisilazane; potassium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;