p-nitrophenylcarbonate hexyl ester

Base Information

• Chemical Name: p-nitrophenylcarbonate hexyl ester
• CAS No.: 67036-15-1
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 67036-15-1.mol

Synonyms:p-nitrophenylcarbonate hexyl ester

Chemical Property of p-nitrophenylcarbonate hexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of p-nitrophenylcarbonate hexyl ester

There total 3 articles about p-nitrophenylcarbonate hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.84%

bis-(p-nitrophenyl) carbonate (5070-13-3) → p-nitrophenylcarbonate hexyl ester (67036-15-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 - 30 ℃;

Reference yield: 80.0%

4-Nitrophenyl chloroformate (7693-46-1) + hexan-1-ol (111-27-3) → p-nitrophenylcarbonate hexyl ester (67036-15-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 68.71%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + n-hexyl chloroformate (6092-54-2) → p-nitrophenylcarbonate hexyl ester (67036-15-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 5 ℃;

upstream raw materials:

4-Nitrophenyl chloroformate

hexan-1-ol

bis-(p-nitrophenyl) carbonate

4-nitro-phenol

Downstream raw materials:

dabigatran etexilate

ethyl 3-(1-{2-[({4-[amino({[(hexyloxy)carbonyl]imino})methyl]phenyl}amino)methyl]-1-methyl-1H-1,3-benzodiazol-5-yl}-N-(pyridin-2-yl)formamido)propanoate

Refernces

• 1、 Zhang, Qiang,Queneau, Yves,Soulère, Laurent. "Biological evaluation and docking studies of new carbamate, thiocarbamate, and hydrazide analogues of ACYL homoserine lactones as vibrio fischeri-quorum sensing modulators". . p. 1 - 12. Retrieved 2020/05/25.
• 2、 -. "PRODRUGS OF KALLIKREIN INHIBITORS". Page/Page column 115. . Retrieved 2018/05/24.