(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

Base Information

Chemical Name:(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal
CAS No.:1417995-94-8
Molecular Formula:C₂₆H₃₈O₄Si
Molecular Weight:442.671
Hs Code.:

Synonyms:(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

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Chemical Property of (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

Chemical Property:

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Technology Process of (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

There total 9 articles about (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1417996-01-0
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

: 1417995-94-8
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/ejoc.201201119

Reference yield:

: 1417995-98-2
(R)-4-benzyl-3-[(2R,4R)-4-(methoxymethoxy)-2-methylhept-6-enoyl]oxazolidin-2-one

: 1417995-94-8
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

3.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

4.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/ejoc.201201119

Reference yield:

: 1417995-97-1
(R)-4-benzyl-3-[(S)-4-(methoxymethoxy)hept-6-enoyl]oxazolidin-2-one

: 1417995-94-8
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptanal

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 3.5 h / -75 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: Dess-Martin periodane / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/ejoc.201201119