(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

Base Information

Chemical Name:(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol
CAS No.:1417996-01-0
Molecular Formula:C₂₆H₄₀O₄Si
Molecular Weight:444.687
Hs Code.:

Synonyms:(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

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Chemical Property of (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

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Technology Process of (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

There total 8 articles about (4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1417996-00-9
(5R,7R)-5-allyl-7,11,11-trimethyl-10,10-diphenyl-2,4,9-trioxa-10-siladodecane

: 1417996-01-0
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

Guidance literature:: (5R,7R)-5-allyl-7,11,11-trimethyl-10,10-diphenyl-2,4,9-trioxa-10-siladodecane; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201201119

Reference yield:

: 1417995-98-2
(R)-4-benzyl-3-[(2R,4R)-4-(methoxymethoxy)-2-methylhept-6-enoyl]oxazolidin-2-one

: 1417996-01-0
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

3.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/ejoc.201201119

Reference yield:

: 1417995-97-1
(R)-4-benzyl-3-[(S)-4-(methoxymethoxy)hept-6-enoyl]oxazolidin-2-one

: 1417996-01-0
(4R,6R)-7-(tert-butyldiphenylsilyloxy)-4-(methoxymethoxy)-6-methylheptan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 3.5 h / -75 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/ejoc.201201119