3-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2-MERCAPTO-3H-QUINAZOLIN-4-ONE

Base Information

• Chemical Name: 3-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
• CAS No.: 361150-63-2
• Molecular Formula: C₁₈H₁₈N₂O₃S
• Molecular Weight: 342.419
• Mol file: 361150-63-2.mol

Synonyms:3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one

Chemical Property of 3-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2-MERCAPTO-3H-QUINAZOLIN-4-ONE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-mercapto-3H-quinazolin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2-MERCAPTO-3H-QUINAZOLIN-4-ONE

There total 5 articles about 3-[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-2-MERCAPTO-3H-QUINAZOLIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

isatoic anhydride (118-48-9) + potassium thioacyanate (333-20-0) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → 3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one (361150-63-2)

Guidance literature:

isatoic anhydride; 2-(3,4-dimethoxyphenyl)-ethylamine; In water; at 20 ℃; for 1h; Green chemistry;

potassium thioacyanate; With acetic acid; In water; for 3h; Heating; Green chemistry;

DOI:10.1080/17415993.2017.1325891

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 2-Amino-N-<β-(3,4-dimethoxyphenyl)ethyl>benzamide (125232-06-6) → 3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one (361150-63-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Reflux;

DOI:10.1007/s00706-013-1110-8

Reference yield:

isatoic anhydride (118-48-9) → 3-(2-(3,4-dimethoxyphenyl)ethyl)-2,3-dihydro-2-thioxoquinazolin-4(1H)-one (361150-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 20 °C

2: potassium hydroxide / ethanol / Reflux

With water; potassium hydroxide; In ethanol;

DOI:10.1016/j.bioorg.2018.10.023

upstream raw materials:

isatoic anhydride

2-(3,4-dimethoxyphenyl)-ethylamine

carbon disulfide

2-Amino-N-<β-(3,4-dimethoxyphenyl)ethyl>benzamide