methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

Base Information

Chemical Name:methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside
CAS No.:1318794-34-1
Molecular Formula:C₂₂H₂₆ClFO₇
Molecular Weight:456.896
Hs Code.:

Synonyms:methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

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Chemical Property of methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

Chemical Property:

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Technology Process of methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

There total 8 articles about methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1318794-34-1
methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

1.2: pH 2 - 3 / Cooling with ice

2.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Sealed flask

3.2: 1 h

4.1: methanesulfonic acid / toluene; tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; methanesulfonic acid; diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 67-56-1
methanol

: C₃₃H₅₆ClFO₇Si₄

: 1318794-34-1
methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

Guidance literature:: With methanesulfonic acid; In tetrahydrofuran; toluene; at 20 ℃;

Reference yield:

: 67-56-1
methanol

: 1318794-33-0
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)fluoromethane

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1318794-34-1
methyl 1-{4-chloro-3-[(4-ethyloxyphenyl)fluoromethyl]phenyl}-α/β-D-glucopyranoside

Guidance literature:: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)fluoromethane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Cooling with acetone-dry ice;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; toluene; at -78 ℃; for 1h;

methanol; With methanesulfonic acid; In tetrahydrofuran; toluene; at -78 - 20 ℃;