((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol

Base Information

Chemical Name:((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol
CAS No.:117858-82-9
Molecular Formula:C15H21 N O3
Molecular Weight:263.33214
Hs Code.:
DSSTox Substance ID:DTXSID50555919
Wikidata:Q82437376
Mol file:117858-82-9.mol

Synonyms:117858-82-9;((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol;((3AR,4R,6AS)-5-BENZYL-2,2-DIMETHYL-TETRAHYDRO-[1,3]DIOXOLO[4,5-C]PYRROL-4-YL)-METHANOL;[(3aR,4R,6aS)-5-benzyl-2,2-dimethyl-3a,4,6,6a-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl]methanol;117858-84-1;SCHEMBL9495642;DTXSID50555919;A893280;[(3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-2H,3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl]methanol;4H-1,3-Dioxolo[4,5-c]pyrrole-4-methanol, tetrahydro-2,2-dimethyl-5-(phenylmethyl)-, (3aR,4R,6aS)-;4H-1,3-Dioxolo[4,5-c]pyrrole-4-methanol,tetrahydro-2,2-dimethyl-5-(phenylmethyl)-,(3aR,4R,6aS)-

Suppliers and Price of ((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol 95+%
1g
$ 1980.00

Chemenu
((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol 95%
1g
$ 1865.00

American Custom Chemicals Corporation
((3AR,4R,6AS)-5-BENZYL-2,2-DIMETHYL-TETRAHYDRO-[1,3]DIOXOLO[4,5-C]PYRROL-4-YL)METHANOL 95.00%
5MG
$ 503.11

Alichem
((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol
1g
$ 1600.00

Total 11 raw suppliers

Chemical Property of ((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol

Chemical Property:

PSA：41.93000
LogP:1.32110
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:263.15214353
Heavy Atom Count:19
Complexity:315

Purity/Quality:

97% ^*data from raw suppliers

((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OC2CN(C(C2O1)CO)CC3=CC=CC=C3)C
Isomeric SMILES:CC1(O[C@H]2CN([C@@H]([C@H]2O1)CO)CC3=CC=CC=C3)C

Technology Process of ((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol

There total 9 articles about ((3aR,4R,6aS)-5-Benzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 117858-82-9
(2S,3S,4R)-N-benzyl-2-hydroxymethyl-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:

Reference yield: 68.0%

: 100-52-7
benzaldehyde

: 117770-00-0
(2S,3S,4R)-2-hydroxymethyl-3,4-O-isopropylidenepyrrolidine-3,4-diol

: 117858-82-9
(2S,3S,4R)-N-benzyl-2-hydroxymethyl-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1021/acs.organomet.8b00140

Reference yield:

: 3969-61-7
2,3,5,6-di-isopropyIidene-1,4-dihydroxy-D-mannitol

: 117858-82-9
(2S,3S,4R)-N-benzyl-2-hydroxymethyl-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 4,4-dimethylaminopyridine / pyridine / 2 h / 0 °C

2: 71 percent / 60 h / 60 - 70 °C

3: 80percent aq. acetic acid / 36 h / 50 °C

4: 1.) sodium periodate, 2.) sodium borohydride / 1.) 80percent aq. ethanol, room temp., 30 min, 2.) 80percent aq. ethanol, room temp., 60 min

With sodium tetrahydroborate; sodium periodate; acetic acid; dmap; In pyridine;
DOI:10.1016/S0040-4020(01)81717-8