2-hydroxy-4-nitromalonanilic acid ethyl ester

Base Information

• Chemical Name: 2-hydroxy-4-nitromalonanilic acid ethyl ester
• CAS No.: 43038-58-0
• Molecular Formula: C₁₁H₁₂N₂O₆
• Molecular Weight: 268.226
• Mol file: 43038-58-0.mol

Synonyms:2-hydroxy-4-nitromalonanilic acid ethyl ester

Chemical Property of 2-hydroxy-4-nitromalonanilic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-4-nitromalonanilic acid ethyl ester

There total 6 articles about 2-hydroxy-4-nitromalonanilic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl chlorocarbonylacetate (36239-09-5) + 5-Nitro-2-aminophenol (121-88-0) → 2-hydroxy-4-nitromalonanilic acid ethyl ester (43038-58-0)

Guidance literature:

With triethylamine; In acetone; Ambient temperature;

DOI:10.1016/S0040-4020(01)81765-8

Reference yield: 56.0%

ethanol (64-17-5) + [N-(2-hydroxy-4-nitro)phenyl]malonamic acid (252189-12-1) → 2-hydroxy-4-nitromalonanilic acid ethyl ester (43038-58-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating;

DOI:10.1002/jhet.5570360439

Reference yield:

N,O-bistrimethylsilyl-2-amino-5-nitrophenol (43112-57-8) → 2-hydroxy-4-nitromalonanilic acid ethyl ester (43038-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: various solvent(s) / 72 h / 45 °C / 0.5 Torr

2: 50 percent / MeOH

3: 56 percent / para-toluenesulfonic acid / toluene / 12 h / Heating

With methanol; toluene-4-sulfonic acid; In toluene; 1: Condensation / 2: Hydrolysis / 3: Esterification;

DOI:10.1002/jhet.5570360439

upstream raw materials:

ethyl chlorocarbonylacetate

5-Nitro-2-aminophenol

ethanol

[N-(2-hydroxy-4-nitro)phenyl]malonamic acid

Downstream raw materials:

diethyl malonate

Refernces

• 1、 Ukrainets, Igor V.,Bezugly, Peter A.,Treskach, Vladimir I.,Taran, Svetlana G.,Gorokhova, Olga V.. "Ethyl Esters of Malonanilic Acids. Synthesis and Pyrolysis". . p. 10331 - 10338. Retrieved 2007/10/02.