4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

Base Information

Chemical Name:4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one
CAS No.:104465-82-9
Molecular Formula:C₃₀H₃₉N₃O₆
Molecular Weight:537.656
Hs Code.:

Synonyms:4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

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Chemical Property of 4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

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Technology Process of 4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

There total 9 articles about 4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 104465-81-8
3--3-phenylpropionic acid

: 104465-80-7
4-(2-acetoxyethyl)-2-(3-aminopropyl)-1,2,3,4-tetrahydroisoquinolin-1-one

: 104465-82-9
4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jo00374a035

Reference yield:

: 23007-65-0
2-benzyl-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline

: 104465-82-9
4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: concd. hydrochloric acid, H₂ / 20percent Pd/C / methanol / 24 h / 20 °C / 760 Torr

2: 75 percent / sodium acetate / ethanol / 2 h / Heating

3: 90 percent / 2 h / 100 °C

4: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

5: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

6: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035

Reference yield:

: 104465-76-1
2-(1,2,3,4-tetrahydroisoquinolin-4-yl)ethanol

: 104465-82-9
4-(2-acetoxyethyl)-2-<8-(tert-butoxycarbonyl)-5-oxo-7-phenyl-4,8-diazaoctyl>-1,2,3,4-tetrahydroisoquinolin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / sodium acetate / ethanol / 2 h / Heating

2: 90 percent / 2 h / 100 °C

3: 95 percent / KMnO₄, H₂O / acetone / 1 h / Ambient temperature

4: 95 percent / H₂ / platinum oxide / CHCl₃; ethanol / 8 h / 20 °C / 760 Torr

5: 86 percent / 1-methyl-2-chloropyridinium iodide, triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With potassium permanganate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; sodium acetate; triethylamine; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; acetone;
DOI:10.1021/jo00374a035