2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1393900-43-0
Molecular Formula:C₂₇H₃₀F₃N₅O
Molecular Weight:497.563
Hs Code.:

Synonyms:2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 14 articles about 2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1393900-42-9
2-(2-(2-(2-((4-(piperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

: 1393900-43-0
2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With methanol; sodium tris(acetoxy)borohydride; In water; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1692-25-7
3-pyridylboronic acid

: 1393900-43-0
2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: hydrogenchloride; hydrogen / water; methanol / 48 h / 2068.65 Torr / Inert atmosphere

2.2: 20 h / 20 °C

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 0 °C

3.2: 60 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 42 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 22 h / 20 - 40 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ammonium carbonate; / N,N-dimethyl-formamide; tetrahydrofuran / 45 h / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: sodium tris(acetoxy)borohydride; methanol / water / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 1393900-43-0
2-(2-(2-(2-((4-(1-methylpiperidin-3-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 18 h / 80 °C

2.1: hydrogenchloride; hydrogen / water; methanol / 48 h / 2068.65 Torr / Inert atmosphere

2.2: 20 h / 20 °C

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 0 °C

3.2: 60 h / 0 - 20 °C

4.1: triethylamine / triphenylphosphine; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 42 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 22 h / 20 - 40 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ammonium carbonate; / N,N-dimethyl-formamide; tetrahydrofuran / 45 h / 20 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: sodium tris(acetoxy)borohydride; methanol / water / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; methanol; lithium hydroxide monohydrate; water; hydrogen; ammonium carbonate; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; zinc(II) chloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; tert-butyl alcohol;