methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride

Base Information

• Chemical Name: methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride
• CAS No.: 72683-81-9
• Molecular Formula: C₁₀H₁₃NO₃*ClH
• Molecular Weight: 231.679
• Mol file: 72683-81-9.mol

Synonyms:methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride

Chemical Property of methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride

There total 1 articles about methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (2R)-2-amino-3-(2-hydroxyphenyl)propanoic acid (24008-77-3) → methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride (72683-81-9)

Guidance literature:

With hydrogenchloride; at 20 ℃; Inert atmosphere;

Reference yield: 93.0%

Z-Asp(OBzl)-OH (3479-47-8) + methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride (72683-81-9) → N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-o-hydroxyphenylalanine methyl ester

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; at 0 - 20 ℃; for 14h;

DOI:10.1021/jm00178a013

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + methyl (2R)-2-amino-3-(2-hydroxyphenyl)propanoate hydrochloride (72683-81-9) → methyl N-{[(1,1-dimethylethyl)oxo]carbonyl}-2-hydroxy-L-phenylalaninate (206268-37-3) + methyl (2R)-2-(tert-butoxycarbonylamino)-3-(2-hydroxyphenyl)propanoate

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Overall yield = 5.5 g; Inert atmosphere;

upstream raw materials:

methanol

(2R)-2-amino-3-(2-hydroxyphenyl)propanoic acid

Downstream raw materials:

L-aspartyl-D-o-hydroxyphenylalanine methyl ester

methyl N-{[(1,1-dimethylethyl)oxo]carbonyl}-2-hydroxy-L-phenylalaninate