9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

Base Information

Chemical Name:9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate
CAS No.:1431285-76-5
Molecular Formula:C₂₉H₂₇ClF₃N₃O₅
Molecular Weight:589.999
Hs Code.:

Synonyms:9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

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Chemical Property of 9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

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Technology Process of 9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

There total 19 articles about 9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1297137-35-9
3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-carboxylic acid

: 1431285-75-4
5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

: 1431285-76-5
9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1021/jm400125h

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1431285-76-5
9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 4 h / 20 °C

2: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 23 h

4: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 0.5 h / 0 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400125h

Reference yield:

: 1431285-71-0
phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

: 1431285-76-5
9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 23 h

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; N,N-dimethyl-formamide / 0.5 h / 0 °C

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400125h