phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

Base Information

• Chemical Name: phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate
• CAS No.: 1431285-71-0
• Molecular Formula: C₂₀H₁₉NO₅
• Molecular Weight: 353.375
• Mol file: 1431285-71-0.mol

Synonyms:phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

Chemical Property of phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate

There total 1 articles about phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + N-methyl-O-(phenylcarbonyl)hydroxylamine hydrochloride (27130-46-7) → phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate (1431285-71-0)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 4h;

DOI:10.1021/jm400125h

Reference yield: 83.0%

[1-(hydroxymethyl)cyclopropyl]methanol (39590-81-3) + phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate (1431285-71-0) → phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate (1431285-72-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 140 ℃; for 24h; Dean-Stark;

DOI:10.1021/jm400125h

Reference yield:

phenylmethyl 4-oxo-3-[(phenylcarbonyl)oxy]-1-piperidinecarboxylate (1431285-71-0) → 5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate (1431285-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 24 h / 140 °C / Dean-Stark

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 23 h

With palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;

DOI:10.1021/jm400125h

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

N-methyl-O-(phenylcarbonyl)hydroxylamine hydrochloride

Downstream raw materials:

phenylmethyl 7-hydroxy-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate

5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

9-{[3-chloro-5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridin-2-yl]carbonyl}-5,12-dioxa-9-azadispiro[2.2.5.2]tridec-7-yl benzoate

phenylmethyl 7-[(phenylcarbonyl)oxy]-5,12-dioxa-9-azadispiro[2.2.5.2]tridecane-9-carboxylate