1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

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Chemical Name:1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin
CAS No.:355390-06-6
Molecular Formula:C₃₄H₃₆N₂O₁₀
Molecular Weight:632.667
Hs Code.:

Synonyms:1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

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Chemical Property of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

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Technology Process of 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

There total 5 articles about 1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 355390-03-3
1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

: 355390-06-6
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 355390-06-6
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

Guidance literature:: Multi-step reaction with 3 steps

1: 2.7 g / DMAP / pyridine / 20 h / 20 °C

2: 64 percent / DCC; DMAP / tetrahydrofuran / 20 h / 20 °C

3: 53 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2

Reference yield:

: 51549-28-1
3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

: 355390-06-6
1-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

Guidance literature:: Multi-step reaction with 4 steps

1: 4.1 g / O₃ / acetonitrile; H₂O / 4 h / 20 °C

2: 2.7 g / DMAP / pyridine / 20 h / 20 °C

3: 64 percent / DCC; DMAP / tetrahydrofuran / 20 h / 20 °C

4: 53 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; ozone; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; water; acetonitrile;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2