1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

Base Information

Chemical Name:1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin
CAS No.:355390-00-0
Molecular Formula:C₃₅H₄₄N₂O₈Si
Molecular Weight:648.828
Hs Code.:

Synonyms:1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

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Chemical Property of 1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

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Technology Process of 1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

There total 2 articles about 1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

: 355390-00-0
1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 20h;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2

Reference yield:

: 51549-28-1
3'-O-(tert-butyldimethylsilyl)-2'-deoxycytidine

: 355390-00-0
1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

Guidance literature:: Multi-step reaction with 2 steps

1: 4.1 g / O₃ / acetonitrile; H₂O / 4 h / 20 °C

2: 2.7 g / DMAP / pyridine / 20 h / 20 °C

With dmap; ozone; In pyridine; water; acetonitrile;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2

Reference yield: 64.0%

: 123-76-2
levulinic acid

: 355390-00-0
1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin

: 355390-03-3
1-[2-deoxy-3-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-5-levulinylhydantoin

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1002/1099-0690(200106)2001:11<2091::AID-EJOC2091>3.0.CO;2-2