51549-28-1 Usage
Description
3'-tert-ButyldiMethylsilyl-2'-deoxycytidine, also known as TBDMS-dC, is a cytidine derivative that plays a crucial role in the field of molecular biology and biotechnology. It is characterized by the presence of a tert-butyldimethylsilyl (TBDMS) group at the 3' position and a deoxyribose sugar at the 2' position, which distinguishes it from other cytidine derivatives. This unique structure allows it to be used in various applications, particularly in the synthesis of oligodeoxynucleotides.
Uses
Used in Molecular Biology and Biotechnology:
3'-tert-ButyldiMethylsilyl-2'-deoxycytidine is used as a building block for the synthesis of oligodeoxynucleotides, which are essential in various molecular biology techniques. The TBDMS-dC derivative provides stability and protection to the oligonucleotides during synthesis, ensuring their proper function in applications such as PCR, DNA sequencing, and gene expression analysis.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3'-tert-ButyldiMethylsilyl-2'-deoxycytidine is used as a key intermediate in the development of novel antiviral and anticancer drugs. Its unique structure allows for the design of more effective and targeted therapeutic agents, potentially leading to improved treatment options for patients.
Used in Research and Development:
3'-tert-ButyldiMethylsilyl-2'-deoxycytidine is also utilized in research and development for the study of nucleic acid structure, function, and interactions. Its unique properties make it an invaluable tool for understanding the molecular mechanisms underlying various biological processes and for the development of new diagnostic and therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 51549-28-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,4 and 9 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51549-28:
(7*5)+(6*1)+(5*5)+(4*4)+(3*9)+(2*2)+(1*8)=121
121 % 10 = 1
So 51549-28-1 is a valid CAS Registry Number.
51549-28-1Relevant articles and documents
Facile and highly selective 5′-desilylation of multisilylated nucleosides
Zhu, Xue-Feng,Williams, Howard J.,Ian Scott
, p. 2305 - 2306 (2007/10/03)
The facile and highly selective 5′-desilylation of multisilylated nucleosides was discussed. The selective 5′-desilylation using aqueous acetic acid can be improved if THF is added as a co-solvent. It was found that the use of THF increases the solubility
