(E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

Base Information

Chemical Name:(E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate
CAS No.:1006597-55-2
Molecular Formula:C₂₇H₂₈BrClN₃O₈P
Molecular Weight:668.865
Hs Code.:

Synonyms:(E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

Suppliers and Price of (E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

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Technology Process of (E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

There total 1 articles about (E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 80646-51-1
1-(3'-chloro-2',3'-dideoxy-β-D-threo-pentofuranosyl)-5-(E)-(2-bromovinyl)-2,4-(1H, 3H)-pyrimidinedione

: 42854-62-6
L-alanine benzyl ester p-toluenesulfonate

: 770-12-7
O-phenyl phosphorodichloridate

: 1006597-55-2
(E)-5-(2-bromovinyl)-3'-chloro-2',3'-dideoxyuridine-5'-[phenyl-(benzyloxy-L-alaninyl)]-phosphate

Guidance literature:: L-alanine benzyl ester p-toluenesulfonate; O-phenyl phosphorodichloridate; With triethylamine; In tetrahydrofuran; at -78 - 20 ℃;

1-(3'-chloro-2',3'-dideoxy-β-D-threo-pentofuranosyl)-5-(E)-(2-bromovinyl)-2,4-(1H, 3H)-pyrimidinedione; With 1-methyl-1H-imidazole; In tetrahydrofuran; at -78 - 20 ℃;