4-Oxazolecarboxylicacid,4,5-dihydro-4-methyl-,methylester,(S)-(9CI)

Base Information

• Chemical Name: 4-Oxazolecarboxylicacid,4,5-dihydro-4-methyl-,methylester,(S)-(9CI)
• CAS No.: 117176-06-4
• Molecular Formula: C6H9 N O3
• Molecular Weight: 143.142
• Mol file: 117176-06-4.mol

Synonyms:4-Oxazolecarboxylicacid, 4,5-dihydro-4-methyl-, methyl ester, (S)- (9CI)

Chemical Property of 4-Oxazolecarboxylicacid,4,5-dihydro-4-methyl-,methylester,(S)-(9CI)

Chemical Property:

• PSA: 47.89000
• LogP: -0.58780

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Oxazolecarboxylicacid,4,5-dihydro-4-methyl-,methylester,(S)-(9CI)

There total 1 articles about 4-Oxazolecarboxylicacid,4,5-dihydro-4-methyl-,methylester,(S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 2-isocyanopropanoate (39748-15-7,33115-74-1) → (S)-4-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (117176-06-4)

Guidance literature:

<(R)-(S)-2a>; In dichloromethane; for 40h; Yield given; Ambient temperature; catalyst: compound from bis(cyclohexyl isocyanide)gold(I) tetrafluoroborate, and (R)-N-methyl-N-<2-(dimethylamino)ethyl>-1-<(S)-1',2-bis(diphenylphosphino)ferrocenyl>ethylamine <(R)-(S)-2a>;

DOI:10.1016/S0040-4039(00)80063-5

Reference yield:

(S)-4-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (117176-06-4) → (S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid (3398-40-1,5424-29-3,16820-18-1,81132-44-7)

Guidance literature:

With hydrogenchloride; at 80 ℃; for 6h; Yield given;

DOI:10.1016/S0040-4039(00)80063-5

Reference yield:

(S)-4-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (117176-06-4) → (S)-methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride (114396-63-3,134899-86-8)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1016/S0040-4039(00)80063-5

upstream raw materials:

formaldehyd

methyl 2-isocyanopropanoate

Downstream raw materials:

(S)-(+)-2-amino-2-methyl-3-hydroxypropanoic acid

(S)-methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride