Technology Process of (E)-3-{2-Benzyloxy-5-[(1S,2S)-2-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-phenyl}-acrylic acid ethyl ester
There total 7 articles about (E)-3-{2-Benzyloxy-5-[(1S,2S)-2-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-phenyl}-acrylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / imidazole / CH2Cl2 / Ambient temperature
2: 90 percent / NaH / toluene; dimethylsulfoxide / from 0 degC to room t.
3: 80 percent / KH / dimethylformamide / Ambient temperature
4: 90 percent / K2CO3 / dimethylformamide / 95 °C
5: 1.) Br2; 2.) Et4NBr, ground sieves (4 Angstroem) / 1.) CH2Cl2, 0 degC; 2.) DMF, room t.
With
1H-imidazole; 4 A molecular sieve; tetraethylammonium bromide; bromine; potassium hydride; sodium hydride; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(96)00713-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 90 percent / K2CO3 / dimethylformamide / 95 °C
2: 1.) Br2; 2.) Et4NBr, ground sieves (4 Angstroem) / 1.) CH2Cl2, 0 degC; 2.) DMF, room t.
With
4 A molecular sieve; tetraethylammonium bromide; bromine; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00713-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / NaH / toluene; dimethylsulfoxide / from 0 degC to room t.
2: 80 percent / KH / dimethylformamide / Ambient temperature
3: 90 percent / K2CO3 / dimethylformamide / 95 °C
4: 1.) Br2; 2.) Et4NBr, ground sieves (4 Angstroem) / 1.) CH2Cl2, 0 degC; 2.) DMF, room t.
With
4 A molecular sieve; tetraethylammonium bromide; bromine; potassium hydride; sodium hydride; potassium carbonate;
In
dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(96)00713-7
