N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Base Information

Chemical Name:N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine
CAS No.:509142-63-6
Molecular Formula:C₁₇H₂₅N₅
Molecular Weight:299.419
Hs Code.:

N<sup>2</sup>-[cis-4-(aminomethyl)cyclohexyl]-N<sup>4</sup>,N<sup>4</sup>-dimethylquinazoline-2,4-diamine

Synonyms:N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Suppliers and Price of N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

There total 11 articles about N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 509142-56-7
benzyl [(cis-4-{[4-(dimethylamino)quinazolin-2-yl]amino}cyclohexyl)methyl]carbamate

: 509142-63-6
N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 60h;
DOI:10.1016/j.bmc.2005.12.052

Reference yield:

: 509143-00-4
cis-(4-aminomethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 509142-63-6
N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: 25.3 g / triethylamine / CH₂Cl₂ / 16 h / 20 °C

2: 95 percent / hydrogen chloride / ethyl acetate / 3 h / 20 °C

3: 84 percent / propan-2-ol / 168 h / Heating

4: hydrogen / Pd-C / methanol / 60 h / 50 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/j.bmc.2005.12.052

Reference yield:

: 364385-64-8
cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester

: 509142-63-6
N²-[cis-4-(aminomethyl)cyclohexyl]-N⁴,N⁴-dimethylquinazoline-2,4-diamine

Guidance literature:: Multi-step reaction with 7 steps

1: 301 g / lithium aluminum hydride / diethyl ether / 2 h / 20 °C

2: 27.5 g / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 60 h / 20 °C

3: hydrazine hydrate / ethanol / 2.25 h / Heating

4: 25.3 g / triethylamine / CH₂Cl₂ / 16 h / 20 °C

5: 95 percent / hydrogen chloride / ethyl acetate / 3 h / 20 °C

6: 84 percent / propan-2-ol / 168 h / Heating

7: hydrogen / Pd-C / methanol / 60 h / 50 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1016/j.bmc.2005.12.052