1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

Base Information

Chemical Name:1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane
CAS No.:221123-63-3
Molecular Formula:C₂₃H₂₉FINO₄
Molecular Weight:529.39
Hs Code.:

Synonyms:1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

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Chemical Property of 1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

There total 12 articles about 1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026879-23-1
methanesulfonic acid 1-[2-(4-fluoro-3-nitro-phenyl)-ethyl]-5-(3-isopropoxy-4-methoxy-phenyl)-pentyl ester

: 221123-63-3
1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

Guidance literature:: With sodium iodide; In acetone; for 24h; Heating;
DOI:10.1021/jo981844s

Reference yield:

: 221123-51-9
4-fluoro-3-nitrobenzyl iodide

: 221123-63-3
1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

1.2: 76 percent / tetrahydrofuran / 1 h / 0 °C

2.1: LiCl / dimethylsulfoxide

3.1: NaBH₄ / ethanol

4.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.1: 429.3 mg / NaI / acetone / 24 h / Heating

With sodium tetrahydroborate; sodium hydride; triethylamine; sodium iodide; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetone; 1.1: Metallation / 1.2: Alkylation / 2.1: Decarboxylation / 3.1: Reduction / 4.1: Esterification / 5.1: Substitution;
DOI:10.1021/jo981844s

Reference yield:

: 129150-61-4
3-(3-hydroxy-4-methoxyphenyl)-propionic acid methyl ester

: 221123-63-3
1-(4-fluoro-3-nitrophenyl)-7-(3-isopropoxy-4-methoxyphenyl)-3-iodoheptane

Guidance literature:: Multi-step reaction with 10 steps

1.1: 96 percent / K₂CO₃ / dimethylformamide / 24 h / 60 °C

2.1: 97 percent / LAH / tetrahydrofuran / 45 h / 0 °C

3.1: pyridine / 20 °C

4.1: 1.31 g / NaI / acetone / Heating

5.1: LDA / tetrahydrofuran / 0.33 h / 0 °C

5.2: 80 percent / tetrahydrofuran / 0.33 h / 0 °C

6.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

6.2: 76 percent / tetrahydrofuran / 1 h / 0 °C

7.1: LiCl / dimethylsulfoxide

8.1: NaBH₄ / ethanol

9.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

10.1: 429.3 mg / NaI / acetone / 24 h / Heating

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; sodium iodide; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 1.1: Etherification / 2.1: Reduction / 3.1: Tosylation / 4.1: Substitution / 5.1: Metallation / 5.2: Alkylation / 6.1: Metallation / 6.2: Alkylation / 7.1: Decarboxylation / 8.1: Reduction / 9.1: Esterification / 10.1: Substitution;
DOI:10.1021/jo981844s