129150-61-4

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-(3-HYDROXY-4-METHOXYPHENYL)PROPANOATE is used as a synthetic intermediate for the preparation of pharmaceuticals. Its chemical properties make it suitable for the development of new drugs and medications, contributing to the advancement of healthcare and medical treatments.

InChI:InChI=1/C11H14O4/c1-14-10-5-3-8(7-9(10)12)4-6-11(13)15-2/h3,5,7,12H,4,6H2,1-2H3

Upstream product

• 97966-29-5 methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate 
• 16980-82-8 3-(3-hydroxy-4-methoxyphenyl)-acrylic acid methyl ester 
• 537-73-5 trans-3-hydroxy-4-methoxycinnamic acid 
• 621-59-0 isovanillin 
• 67-56-1 methanol 
• 1135-15-5 dihydroisoferulic acid 

Downstream Products

• 6305-53-9 3-(3-benzyloxy-4-methoxy-phenyl)-propionic acid methyl ester 
• 42920-05-8 6-Methoxy-diphenylether-3,4'-β,β'-dipropionsaeuredimethylester 
• 1135-15-5 dihydroisoferulic acid 
• 875473-31-7 3-[4-methoxy-3-(4-vinylphenoxy)phenyl] propionic acid methyl ester 
• 875473-26-0 allyl 3-[3-(4-formylphenoxy)-4-methoxyphenyl]-propanoate 
• 875473-29-3 2-oxoethyl-3-{3-[4-(bromomethyl)phenoxy]-4-methoxyphenyl}propanoate 
• 875473-32-8 3-[4-methoxy-3-(4-vinylphenoxy)phenyl] propionic acid allyl ester 
• 875473-27-1 allyl 3-{3-[4-(hydroxymethyl)phenoxy]-4-methoxyphenyl}propanoate 
• 875473-28-2 allyl 3-{3-[4-(bromomethyl)phenoxy]-4-methoxyphenyl}propanoate 
• 875473-34-0 allyl 3-{3-[4-(chloromethyl)phenoxy]-4-methoxyphenyl}propanoate 
• 875473-35-1 3-{3-[4-(dimethoxyphosphorylmethyl)phenoxy]-4-methoxyphenyl}propionic acid allyl ester 
• 1459809-11-0 N-(4-((4-aminophenyl)diazenyl)phenethyl)-7,8-dihydroxy-4,5-dihydro-1Hbenzo[c]azepine-2(3H)-carbothioamide 
• 1459809-10-9 7,8-dihydroxy-N-(4-((4-nitrophenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo-[c]azepine-2(3H)-carbothioamide 
• 1459809-09-6 7,8-dihydroxy-N-(4-((4-(trifluoromethyl)phenyl)diazenyl)phenethyl)-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carbothioamide 

Relevant academic research and scientific papers

Gram-scale enantioselective formal synthesis of morphine through an orth?para oxidative phenolic coupling strategy

A gram-scale catalytic enantioselective formal synthesis of morphine is described. The key steps of the synthesis involve an orth?para oxidative phenolic coupling and a highly diastereoselective "desymmetrization" of the resulting cyclohexadienone that generates three of the four morphinan ring junction stereocenters in one step. The stereochemistry is controlled from a single carbinol center installed through catalytic enantioselective hydrogenation. These transformations enabled the preparation of large quantities of key intermediates and could support a practical and scalable synthesis of morphine and related derivatives.

Optical control of TRPV1 channels

Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity. Copyright

A new approach to combretastatin D2

A concise and convergent route to combretastatin D2 is described together with some preliminary biological data. The Royal Society of Chemistry 2006.

A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist

A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist, has been accomplished from isovanillin in 8 steps via an efficient intramolecular Mannich cyclization.

An Ullmann ether reaction involving an alkynyl substrate: A convergent route to a combretastatin intermediate

We found that we could employ a disubstituted alkynyl halide in an Ullmann ether reaction to produce the cis-alkene intermediate 3 of the combretastatin natural products.