1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane

Base Information

• Chemical Name: 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane
• CAS No.: 503606-98-2
• Molecular Formula: C₂₆H₄₀OSi₂
• Molecular Weight: 424.774
• Mol file: 503606-98-2.mol

Synonyms:1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane

Chemical Property of 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane

There total 4 articles about 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-iodo-propane (75-30-9) + dimethyl(phenyl)silyllithium (3839-31-4) + cyclohexanylcarbonyl chloride (2719-27-9) → C23H34OSi2 + 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane (503606-98-2)

Guidance literature:

dimethyl(phenyl)silyllithium; cyclohexanylcarbonyl chloride; In tetrahydrofuran; toluene; at -78 ℃; for 1h;

2-iodo-propane; In tetrahydrofuran; toluene; at -78 - 20 ℃;

DOI:10.1002/1522-2675(200210)85:10<3349::AID-HLCA3349>3.0.CO;2-K

Reference yield: 48.0%

2-iodo-propane (75-30-9) + 1,1-biscyclohexanemethanol (155397-15-2) → 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane (503606-98-2)

Guidance literature:

1,1-biscyclohexanemethanol; With [2,2]bipyridinyl; n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 0.0833333h;

2-iodo-propane; In diethyl ether; hexane; for 12h;

DOI:10.1002/1522-2675(200210)85:10<3349::AID-HLCA3349>3.0.CO;2-K

Reference yield:

dimethyl(phenyl)silyllithium (3839-31-4) → 1-cyclohexyl-1-[dimethyl(phenyl)silyl]-1-[dimethyl(phenyl)silyloxy]-2-methylpropane (503606-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 94 percent / tetrahydrofuran; toluene / -78 °C

2.1: BuLi; 2,2'-bipyridine / hexane; diethyl ether / 0.08 h / 0 °C

2.2: 48 percent / hexane; diethyl ether / 12 h

With [2,2]bipyridinyl; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; toluene; 2.1: Brook rearrangement;

DOI:10.1002/1522-2675(200210)85:10<3349::AID-HLCA3349>3.0.CO;2-K

upstream raw materials:

2-iodo-propane

1,1-biscyclohexanemethanol

dimethyl(phenyl)silyllithium

cyclohexanylcarbonyl chloride

Downstream raw materials:

1-cyclohexyl-2-methylpropan-1-one

1-cyclohexyl-2-methylpropan-1-ol