Technology Process of C20H21F3N2O5S2
There total 5 articles about C20H21F3N2O5S2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H22N2O3S;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1h;
N,N-phenylbistrifluoromethane-sulfonimide;
In
tetrahydrofuran;
at -78 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 h / 20 °C / 2068.65 Torr
3.1: hydrogenchloride / tetrahydrofuran; water / 5 h / 0 - 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C
4.2: -78 - 20 °C
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;
1.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 20 h / 20 °C / 2068.65 Torr
3.1: hydrogenchloride / tetrahydrofuran; water / 5 h / 0 - 20 °C
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C
4.2: -78 - 20 °C
With
hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; sodium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;
1.1: |Suzuki Coupling;