2-[Ethyl(methyl)amino]acetamide

Base Information

• Chemical Name: 2-[Ethyl(methyl)amino]acetamide
• CAS No.: 116833-20-6
• Molecular Formula: C₅H₁₂N₂O
• Molecular Weight: 116.163
• DSSTox Substance ID: DTXSID00451558
• Wikidata: Q82271634
• Mol file: 116833-20-6.mol

Synonyms:116833-20-6;2-[ethyl(methyl)amino]acetamide;2-(Ethyl(methyl)amino)acetamide;2-(ETHYLMETHYLAMINO)ACETAMIDE;Acetamide,2-(ethylmethylamino)-;2-(methyl-ethylamino)acetamide;SCHEMBL1132413;DTXSID00451558;AKOS010197781

Chemical Property of 2-[Ethyl(methyl)amino]acetamide

Chemical Property:

• Boiling Point: 215.2±23.0 °C(Predicted)
• PKA: 16.04±0.40(Predicted)
• PSA: 47.32000
• Density: 0.975±0.06 g/cm3(Predicted)
• LogP: 0.57310
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 116.094963011
• Heavy Atom Count: 8
• Complexity: 82.5

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(C)CC(=O)N

Technology Process of 2-[Ethyl(methyl)amino]acetamide

There total 1 articles about 2-[Ethyl(methyl)amino]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Ethylmethylamine (624-78-2) + Chloroacetamide (79-07-2) → 2-(methyl-ethylamino)acetamide (116833-20-6)

Guidance literature:

Reference yield: 73.0%

2-(methyl-ethylamino)acetamide (116833-20-6) + (6R,7R)-3-[(Z)-4-(Diphenoxy-phosphoryloxy)-but-2-enyl]-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester (157463-20-2) → Carbamoylmethyl-ethyl-[(Z)-4-((6R,7R)-2-(4-methoxy-benzyloxycarbonyl)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-yl)-but-2-enyl]-methyl-ammonium; iodide

Guidance literature:

With sodium iodide;

DOI:10.7164/antibiotics.49.1179

Reference yield:

2-(methyl-ethylamino)acetamide (116833-20-6) + 3-[(Z)-4-(Diphenoxy-phosphoryloxy)-but-2-enyl]-7-[2-[(Z)-methoxyimino]-2-(2-trityl-thiazol-4-yl)-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid pentamethylphenyl ester → Carbamoylmethyl-ethyl-((Z)-4-{7-[2-[(Z)-methoxyimino]-2-(2-trityl-thiazol-4-yl)-acetylamino]-8-oxo-2-pentamethylphenyloxycarbonyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-yl}-but-2-enyl)-methyl-ammonium; iodide

Guidance literature:

With sodium iodide; Yield given. Multistep reaction; 2.) CH₃CN, 4 degC, 12 h;

DOI:10.1016/S0040-4039(00)60733-5

upstream raw materials:

N-Ethylmethylamine

Chloroacetamide