Technology Process of N-[3-(2-chlorophenyl)-1-(piperidin-1-ylcarbonyl)propyl]-1H-indole-4-sulfonamide
There total 9 articles about N-[3-(2-chlorophenyl)-1-(piperidin-1-ylcarbonyl)propyl]-1H-indole-4-sulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; HATU;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere
2.1: zinc(II) iodide / diethyl ether / 0.25 h
2.2: 5 h / 50 °C
3.1: hydrogenchloride; water / 12 h / 100 °C
3.2: 2 h
3.3: pH 4
4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
4.2: 3 h
5.1: trifluoroacetic acid / dichloromethane / 1 h
5.2: 12 h
6.1: sodium hydroxide / 1,4-dioxane
6.2: pH 3
7.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide
With
4-methyl-morpholine; hydrogenchloride; dmap; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; trifluoroacetic acid; sodium hydroxide;
palladium diacetate; zinc(II) iodide;
In
1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: zinc(II) iodide / diethyl ether / 0.25 h
1.2: 5 h / 50 °C
2.1: hydrogenchloride; water / 12 h / 100 °C
2.2: 2 h
2.3: pH 4
3.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
3.2: 3 h
4.1: trifluoroacetic acid / dichloromethane / 1 h
4.2: 12 h
5.1: sodium hydroxide / 1,4-dioxane
5.2: pH 3
6.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide
With
4-methyl-morpholine; hydrogenchloride; dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; trifluoroacetic acid; sodium hydroxide;
zinc(II) iodide;
In
1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
