methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

Base Information

Chemical Name:methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate
CAS No.:1092938-37-8
Molecular Formula:C₂₄H₂₅N₃O₄S
Molecular Weight:451.546
Hs Code.:

Synonyms:methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

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Chemical Property of methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

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Technology Process of methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

There total 6 articles about methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 6165-68-0
thiophene boronic acid

: 1073630-64-4
6-{[6-bromo-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester

: 1092938-37-8
methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 90 ℃; for 16h;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1092938-37-8
methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethylammonium chloride; potassium fluoride / dichloromethane; xylene / 15 h / 160 °C

2.1: ethanol / 0.17 h / 85 °C

2.2: 15 h / 85 °C

3.1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

4.1: potassium carbonate / acetonitrile / 18 h / Reflux

5.1: N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 90 °C

With potassium fluoride; N-Bromosuccinimide; N,N-dimethylammonium chloride; potassium carbonate; N,N-diethylaniline; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrachloromethane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene; acetonitrile; xylene;

Reference yield:

: 141764-49-0
5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4(3H)-one

: 1092938-37-8
methyl 6-{[5-(4-methoxyphenyl)-6-(2-thienyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

2: potassium carbonate / acetonitrile / 18 h / Reflux

3: N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 16 h / 90 °C

With N-Bromosuccinimide; potassium carbonate; N,N-diethylaniline; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrachloromethane; 1,2-dimethoxyethane; water; toluene; acetonitrile;