4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1204331-27-0
Molecular Formula:C₁₈H₂₂F₃NO₄
Molecular Weight:373.372
Hs Code.:

Synonyms:4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

There total 10 articles about 4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1204331-48-5
4-(4-methoxycarbonyl-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

: 1204331-27-0
4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogenchloride; potassium carbonate; In methanol; water; at 20 ℃; for 16h;
DOI:10.1021/jm300601d

Reference yield: 98.0%

: 1204331-35-0
4-(4-carboxy-2-trifluoromethyl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1204331-27-0
4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; under 3102.97 Torr; Product distribution / selectivity;

Reference yield:

: 161622-14-6
4-bromo-3-(trifluoromethyl)benzoic acid

: 1204331-27-0
4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 80 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C

3: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

4: potassium carbonate; hydrogenchloride / methanol; water / 16 h / 20 °C

With hydrogenchloride; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; methanol; water; 2: |Suzuki Coupling;
DOI:10.1021/jm300601d